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Molding Cell Beads for Rapid Construction of Macroscopic 3D Tissue Architecture
Author(s) -
Matsunaga Yukiko T.,
Morimoto Yuya,
Takeuchi Shoji
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201004375
Subject(s) - bead , silicone , materials science , fabrication , microfluidics , stacking , nanotechnology , molding (decorative) , 3d printing , template , biomedical engineering , composite material , engineering , chemistry , medicine , alternative medicine , organic chemistry , pathology
A microfluidic system was used to prepare a large number of size‐controlled collagen gel beads to form microtissue units, “cell beads”, as tissue building blocks. By stacking cell beads into a doll‐shaped silicone chamber, millimeter‐thick tissue with uniform cell density was formed rapidly. The bead structure allowed the application into the 3D printing, achieving automated geometrical control of the formed tissues for the fabrication of functional complex tissues.