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Cell‐Based Drug Delivery Devices Using Phagocytosis‐Resistant Backpacks
Author(s) -
Doshi Nishit,
Swiston Albert J.,
Gilbert Jonathan B.,
Alcaraz Maria L.,
Cohen Robert E.,
Rubner Michael F.,
Mitragotri Samir
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201004074
Subject(s) - phagocytosis , drug , drug delivery , materials science , cell , macrophage , pharmacology , nanotechnology , medicine , immunology , biology , in vitro , biochemistry
Macrophages are recruited at the diseased site in several pathological conditions. Here, we describe a novel method of utilizing their unique properties for targeted drug delivery. Cellular backpacks are designed that ride on macrophage surfaces without affecting cell functions or getting internalized. These backpacks can be used as multimodal therapeutic and diagnostic agents.