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Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy
Author(s) -
Brulé Séverine,
Levy Michael,
Wilhelm Claire,
Letourneur Didier,
Gazeau Florence,
Ménager Christine,
Le Visage Catherine
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201003763
Subject(s) - hyperthermia , doxorubicin , materials science , magnetic hyperthermia , drug , magnetic nanoparticles , in vitro , nanoparticle , nanotechnology , hyperthermia therapy , biophysics , pharmacology , biomedical engineering , cancer research , chemotherapy , medicine , chemistry , biochemistry , biology
Alginate microbeads with iron oxide nanoparticle heaters that carry doxo‐rubicin are investigated in vitro for simultaneous drug targeting and local heat generation (hyperthermia). Application of an alternative magnetic field (AMF) causes magnetic‐hyperthermia‐enhanced doxorubicin release. The AMF‐triggered drug release and hyperthermia exhibit synergistic effects and result in significant tumor cell death.