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Protein Tethering into Multiscale Geometries by Covalent Subtractive Printing
Author(s) -
Coyer Sean R.,
Delamarche Emmanuel,
García Andrés J.
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201003744
Subject(s) - ethylene glycol , materials science , nanotechnology , covalent bond , micrometer , monolayer , self assembly , self assembled monolayer , organic chemistry , chemistry , optics , physics
High‐resolution patterns of proteins at multiple length scales are printed by a facile and flexible strategy using a flat elastomeric stamp and direct covalent immobilization onto mixed self‐assembled monolayers of tri(ethylene glycol)‐ and carboxylic acid–hexa(ethylene glycol)‐terminated alkanethiols on gold‐coated substrates. This is a robust method for generating complex protein arrays with precise control over micrometer‐ and nanometer‐scale pattern geometries while maintaining a protein‐adsorption‐resistant background.