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Cooperation of Biological and Mechanical Signals in Cardiac Progenitor Cell Differentiation
Author(s) -
Pagliari Stefania,
VilelaSilva Ana Cristina,
Forte Giancarlo,
Pagliari Francesca,
Mandoli Corrado,
Vozzi Giovanni,
Pietronave Stefano,
Prat Maria,
Licoccia Silvia,
Ahluwalia Arti,
Traversa Enrico,
Minieri Marilena,
Di Nardo Paolo
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201003479
Subject(s) - materials science , progenitor cell , myocyte , stem cell , cardiac muscle , adhesion , niche , nanotechnology , cell , microbiology and biotechnology , biomedical engineering , biology , anatomy , biochemistry , composite material , medicine
Three‐dimensional cardiac tissue‐specific scaffolds made of poly‐lactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac‐like stiffness. The mechano‐physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.