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Self‐Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness
Author(s) -
Xing Yongzheng,
Cheng Enjun,
Yang Yang,
Chen Ping,
Zhang Tao,
Sun Yawei,
Yang Zhongqiang,
Liu Dongsheng
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201003343
Subject(s) - self healing hydrogels , dna , materials science , linker , construct (python library) , nanotechnology , computer science , biochemistry , biology , polymer chemistry , programming language , operating system
An easy and versatile approach to construct DNA hydrogels is reported. The DNA building blocks, a Y‐scaffold and a linker, can self‐assemble into DNA hydrogels by the hybridization of their “sticky ends”. It is shown that the DNA hydrogels undergo a sol‐gel transition upon heat or enzymatic treatment, and these responsiveness can be adjusted by tailoring the sequence of the building blocks.