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Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules
Author(s) -
Yan Yan,
Ochs Christopher J.,
Such Georgina K.,
Heath Joan K.,
Nice Edouard C.,
Caruso Frank
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201003162
Subject(s) - materials science , multiple drug resistance , cancer cell , endocytosis , biodegradable polymer , in vitro , polymer , drug , drug resistance , layer (electronics) , nanotechnology , intracellular , cancer , pharmacology , biochemistry , cell , chemistry , microbiology and biotechnology , medicine , biology , composite material
Biodegradable polymer capsules with drug‐loaded multilayers were prepared through click chemistry via layer‐by‐layer assembly. The capsules can efficiently release incorporated drug by intracellular enzymatic degradation in both sensitive and resistant colorectal cancer cells in vitro . Endocytosis of drug‐loaded capsules leads to bypass of Pgp‐mediated multidrug resistance in cancer cells.