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Surface Functionalization of Porous Coordination Nanocages Via Click Chemistry and Their Application in Drug Delivery
Author(s) -
Zhao Dan,
Tan Songwei,
Yuan Daqiang,
Lu Weigang,
Rezenom Yohannes H.,
Jiang Hongliang,
Wang LiQun,
Zhou HongCai
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201003012
Subject(s) - nanocages , surface modification , polyethylene glycol , click chemistry , materials science , drug delivery , ligand (biochemistry) , porosity , combinatorial chemistry , alkyne , nanotechnology , azide , chemical engineering , polymer chemistry , organic chemistry , chemistry , catalysis , engineering , composite material , biochemistry , receptor
Porous coordination nanocages covered with alkyne groups are synthesized through judicious selection of the ligand and reaction conditions. The surface functionalization via click reaction with azide‐terminated polyethylene glycol turns them into water‐stable colloids, which exhibit controlled release of an anticancer drug 5‐fluorouracil.