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Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels
Author(s) -
Qi Hao,
Du Yanan,
Wang Lianyong,
Kaji Hirokazu,
Bae Hojae,
Khademhosseini Ali
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201002873
Subject(s) - materials science , embryoid body , microscale chemistry , polyethylene glycol , gelatin , tissue engineering , nanotechnology , self healing hydrogels , peg ratio , biophysics , silicone , cellular differentiation , chemical engineering , biomedical engineering , polymer chemistry , chemistry , composite material , biology , adult stem cell , organic chemistry , gene , medicine , biochemistry , mathematics education , mathematics , finance , engineering , economics
A microengineered hybrid hydrogel array is developed containing asymmetrical extracellular matrices [polyethylene‐glycol (PEG) and gelatin methacrylate (GelMA)] to mimic the anisotropic stem cell niche and induce the patterned differentiation of embryoid bodies (EBs). The asymmetrical matrices around individual aggregate of mouse EBs induce polarity and demonstrate the potential of microscale engineered materials for forming tissues.