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Biocompatible Charged and Uncharged Surfaces Using Nanoparticle Films
Author(s) -
Subramani Chandramouleeswaran,
Bajaj Avinash,
Miranda Oscar R.,
Rotello Vincent M.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201002851
Subject(s) - biofouling , polyethylenimine , biocompatible material , materials science , dithiocarbamate , cationic polymerization , fouling , nanoparticle , chemical engineering , nanotechnology , surface modification , zeta potential , polymer chemistry , membrane , chemistry , biomedical engineering , biochemistry , transfection , medicine , engineering , metallurgy , gene
Biocompatible surfaces: Cationic, anionic, and neutral nanoparticles (NPs) were immobilized via dithiocarbamate formation onto polyethylenimine (PEI) films to create biofouling resistant surfaces. These surfaces are designed to bind proteins without denaturation, hence preventing biofouling. Extended incubation of these surfaces with BSA and serum demonstrate minimal fouling, providing a new methodology for generating surfaces resistant towards protein fouling.