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Temperature‐Responsive Polymer Brushes Switching from Bactericidal to Cell‐Repellent
Author(s) -
Laloyaux Xavier,
Fautré Emilie,
Blin Thomas,
Purohit Viswas,
Leprince Jérôme,
Jouenne Thierry,
Jonas Alain M.,
Glinel Karine
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201002538
Subject(s) - ethylene glycol , copolymer , methacrylate , materials science , polymer , magainin , brush , polymer brush , chemical engineering , polymer science , nanotechnology , polymer chemistry , peptide , chemistry , composite material , polymerization , biochemistry , engineering , antimicrobial peptides
The composition of temperature‐responsive copolymer brushes based on oligo(ethylene glycol) methacrylates is tuned to obtain a collapse temperature of ∼35 °C. The chains are grafted by antibacterial magainin I peptide, whose activity is tested at different temperatures against various bacteria. The brushes switch from bactericidal to cell‐repellent below and slightly above 35 °C, respectively, due to the progressive vertical collapse of the brush.