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Endothelial Cell Guidance in 3D Patterned Scaffolds
Author(s) -
Aizawa Yukie,
Wylie Ryan,
Shoichet Molly
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201001855
Subject(s) - materials science , scaffold , agarose , nanotechnology , in vivo , biomedical engineering , biology , microbiology and biotechnology , engineering
Primary endothelial cells are guided in an agarose hydrogel scaffold that is chemically patterned with an immobilized concentration gradient of VEGF165 using multiphoton laser patterning. It is particularly compelling that, in this 3D patterned hydrogel, endothelial cells differentiate to tip and stalk cells, having the morphology that is observed in vivo .