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Reprogramming Directional Cell Motility by Tuning Micropattern Features and Cellular Signals
Author(s) -
Kushiro Keiichiro,
Chang Stephanie,
Asthagiri Anand R.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201001619
Subject(s) - reprogramming , signal (programming language) , simple (philosophy) , modulation (music) , motility , materials science , mechanism (biology) , bar (unit) , scale (ratio) , biological system , computer science , nanotechnology , biology , microbiology and biotechnology , cell , physics , acoustics , biochemistry , philosophy , epistemology , quantum mechanics , meteorology , programming language
Simple geometrical constraints of micropatterned substrates can be used to manipulate the direction and directional persistence of motile cells (scale bar: 20 μm). Modulation of the directional bias is demonstrated by altering pattern parameters and signal pathways.