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Conjugated Oligoelectrolyte Harnessed Polyhedral Oligomeric Silsesquioxane as Light‐Up Hybrid Nanodot for Two‐Photon Fluorescence Imaging of Cellular Nucleus
Author(s) -
Pu KanYi,
Li Kai,
Zhang Xinhai,
Liu Bin
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201001544
Subject(s) - silsesquioxane , nanodot , fluorescence , conjugated system , materials science , nucleus , two photon excitation microscopy , excited state , biophysics , photochemistry , nanotechnology , optics , chemistry , polymer , biology , nuclear physics , physics , microbiology and biotechnology , composite material
A water‐soluble organic/inorganic hybrid nanodot based on polyhedral oligomeric silsesquioxane (POSS) and conjugated oligoelectrolyte is designed and synthesized for two‐photon fluorescence imaging of cellular nucleus, which takes advantage of its small size (∼3.3 nm) that imparts nucleus permeability and substantial DNA‐enhanced two‐photon excited fluorescence that allows illuminating the nucleus with a high contrast.