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Nano‐Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA
Author(s) -
DeMuth Peter C.,
Su Xingfang,
Samuel Raymond E.,
Hammond Paula T.,
Irvine Darrell J.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201001525
Subject(s) - engine department , library science , engineering , computer science , mechanical engineering
Multilayer‐coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3‐labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer self‐assembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II‐GFP–green).