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Encapsulation of Water‐Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery
Author(s) -
Wang Yajun,
Yan Yan,
Cui Jiwei,
HostaRigau Leticia,
Heath Joan K.,
Nice Edouard C.,
Caruso Frank
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201001497
Subject(s) - mesoporous silica , materials science , polymer , template , drug delivery , nanotechnology , mesoporous material , drug , nanoparticle , solvent , chemical engineering , encapsulation (networking) , organic chemistry , chemistry , pharmacology , computer science , medicine , engineering , composite material , catalysis , computer network
Water‐insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle‐mediated layer‐by‐layer assembly. The drug‐loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.