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Dynamically Crosslinked Gold Nanoparticle – Hyaluronan Hydrogels
Author(s) -
Skardal Aleksander,
Zhang Jianxing,
McCoard Lindsi,
Oottamasathien Siam,
Prestwich Glenn D.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201001436
Subject(s) - hyaluronic acid , self healing hydrogels , materials science , nanoparticle , gelatin , extracellular matrix , nanotechnology , colloidal gold , matrix (chemical analysis) , tissue engineering , computer science , biomedical engineering , polymer chemistry , chemistry , biochemistry , anatomy , biology , composite material , medicine
Bioprinting consists of automated deposition of cells and biomaterials to mimic the architecture of a tissue. Gold nanoparticles act as dynamic, multivalent crosslinkers for thiol‐modified hyaluronic acid and gelatin. The resulting synthetic extracellular matrix can be bioprinted into tubular constructs that support cell proliferation and matrix remodeling. The figure shows a view of a tissue construct (containing a fluorescent dye) in the x‐y plane, and the inset shows the print head used.