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Layer‐By‐Layer Assembly of β‐Estradiol Loaded Mesoporous Silica Nanoparticles on Titanium Substrates and Its Implication for Bone Homeostasis
Author(s) -
Hu Yan,
Cai Kaiyong,
Luo Zhong,
Jandt Klaus D.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201000854
Subject(s) - layer (electronics) , mesoporous silica , nanotechnology , nanoparticle , materials science , mesoporous material , drug delivery , titanium , layer by layer , scaffold , biomedical engineering , chemistry , biochemistry , engineering , metallurgy , catalysis
Drug‐loading mesoporous silica nanoparticles that serve as a nanoreservoir‐type drug‐delivery system are successfully attached to titanium substrates via the layer‐by‐layer assembly technique (see scheme). The obtained structure demonstrates great potential for regulating the biological behaviors of osteoblasts/ steoclasts in order to maintain bone homeostasis. The approach we present here may have wide applications in implant technology, tissue engineering, and regenerative medicine.