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Acetal‐Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non‐Phagocytic Cells
Author(s) -
Cohen Joel A.,
Beaudette Tristan T.,
Cohen Jessica L.,
Broaders Kyle E.,
Bachelder Eric M.,
Fréchet Jean M. J.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201000307
Subject(s) - dextran , cationic polymerization , surface modification , degradation (telecommunications) , materials science , acetal , polymer , kinetics , biophysics , gene delivery , chemical engineering , polymer chemistry , genetic enhancement , biochemistry , gene , chemistry , organic chemistry , biology , composite material , engineering , telecommunications , physics , quantum mechanics , computer science
A microparticulate gene delivery system based on biodegradable and acid‐sensitive acetal‐modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and non‐phagocytic cells with minimal toxicity.