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A Microfluidic Hydrogel Capable of Cell Preservation without Perfusion Culture under Cell‐Based Assay Conditions
Author(s) -
Xu Yan,
Sato Kae,
Mawatari Kazuma,
Konno Tomohiro,
Jang Kihoon,
Ishihara Kazuhiko,
Kitamori Takehiko
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201000006
Subject(s) - microfluidics , flexibility (engineering) , materials science , phosphorylcholine , cell , viability assay , cell culture , polymer , microbiology and biotechnology , nanotechnology , biology , biochemistry , genetics , statistics , mathematics , composite material
A 2‐methacryloyloxyethyl phosphorylcholine (MPC) polymer hydrogel exhibits a remarkable ability to preserve cells on microfluidic chips without perfusion culture under cell‐based assay conditions, with characteristics of maintenance of high cell viability, restraint of cell proliferation, and minimization of cellular function loss over a period of days and weeks. This would establish a revolutionary flexibility for cell‐based applications.