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Enzyme‐Responsive Hydrogels: Dynamic, 3D‐Pattern Formation Within Enzyme‐Responsive Hydrogels (Adv. Mater. 41/2009)
Author(s) -
Straley Karin S.,
Heilshorn Sarah C.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200990152
Subject(s) - self healing hydrogels , biomaterial , materials science , neural tissue engineering , neurite , tissue engineering , enzyme , biophysics , nanotechnology , microbiology and biotechnology , biomedical engineering , biochemistry , polymer chemistry , biology , medicine , in vitro
On p. 4148 , Sarah Heilshorn and Karin Straley demonstrate the design of a family of adaptive protein polymers with highly tunable and predictable degradation rates suitable for complex tissue‐engineering applications. The cover image shows fluorescently labeled neurons grow and extend neurites on a protein‐engineered biomaterial. Enzymes secreted by the neurons trigger selective degradation of specific regions of the biomaterial, allowing dynamic 3D patterns to emerge over time. Microscope images were acquired by Karin Straley. Digital art by Chelsea Castillo.