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Nanoelectronic Biosensing of Dynamic Cellular Activities Based on Nanostructured Materials
Author(s) -
Huang Yinxi,
Chen Peng
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200904235
Subject(s) - nanotechnology , biosensor , materials science , biomolecule , nanowire , carbon nanotube , silicon nanowires
Detecting subtle cellular activities that occur dynamically as regulated temporally and spatially by molecular machinery is of obvious importance in fundamental biology as well as in drug discovery. Additionally, it demands fast and sensitive detection modality. The emerging nanoelectronic biosensors based on nanostructured materials have shown promising potential to resolve the dynamic biological processes of living cells with high sensitivity and high temporal and spatial resolution. Here, the recent advances in the nanoelectronic biosensing of regulated secretion of biomolecules and bioelectrical activities of ion channels using carbon nanotubes and silicon nanowires are briefly reviewed. The perspectives and key issues of future development are also discussed.