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Dual‐Sensitive Micellar Nanoparticles Regulate DNA Unpacking and Enhance Gene‐Delivery Efficiency
Author(s) -
Jiang Xuan,
Zheng Yiran,
Chen Hunter H.,
Leong Kam W.,
Wang TzaHuei,
Mao HaiQuan
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200903933
Subject(s) - materials science , gene delivery , dna , nanoparticle , unpacking , ionic strength , biophysics , nanotechnology , ionic bonding , transgene , gene , genetic enhancement , biochemistry , biology , chemistry , ion , organic chemistry , philosophy , aqueous solution , linguistics
Reversibly crosslinked micellar nanoparticles that are capable of releasing encapsulated DNA in response to a reduction microenvironment and physiological ionic strength are synthesized for gene delivery. The dual‐sensitive nanoparticles exhibit significantly enhanced complex and colloidal stability, yield more sustained DNA unpacking in cytosols, and mediate enhanced and more prolonged transgene expression for at least 10 days.