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Nanotemplating of Biodegradable Polymer Membranes for Constant‐Rate Drug Delivery
Author(s) -
Bernards Daniel A.,
Desai Tejal A.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200903439
Subject(s) - nanoporous , polycaprolactone , materials science , membrane , biocompatibility , drug delivery , nanotechnology , polymer , oxide , chemistry , composite material , biochemistry , metallurgy
A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic biocompatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein‐based therapeutics.