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pH‐Sensitive Water‐Soluble Nanospheric Imprinted Hydrogels Prepared as Horseradish Peroxidase Mimetic Enzymes
Author(s) -
Chen Zhiyong,
Xu Li,
Liang Yuan,
Zhao Meiping
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200903122
Subject(s) - horseradish peroxidase , self healing hydrogels , cationic polymerization , materials science , monomer , catalysis , chemical engineering , polymer , peroxidase , polymer chemistry , nanoparticle , biocompatible material , nanotechnology , organic chemistry , chemistry , enzyme , engineering , composite material , medicine , biomedical engineering
Water‐soluble hydrogel nanoparticles have been synthesized by the incorporation of the stimuli‐sensitive monomer of N ‐isopropylacrylamide (NIPAM) to a catalytic, molecularly imprinted system. The unique properties of pNIPAM copolymerized with cationic and anionic polymers offers a homogenously biocompatible catalytic system with switchable response to pH change. The maximum catalytic efficiency can thus be significantly increased.