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Engineering a Material Surface for Drug Delivery and Imaging using Layer‐by‐Layer Assembly of Functionalized Nanoparticles
Author(s) -
Soike Thomas,
Streff Amanda K.,
Guan Chenxia,
Ortega Ryan,
Tantawy Mohammed,
Pino Christopher,
Shastri V. Prasad
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200903069
Subject(s) - materials science , layer by layer , nanoparticle , nanotechnology , surface modification , polyelectrolyte , drug delivery , layer (electronics) , surface engineering , chemical engineering , polymer , composite material , engineering
Layer‐by‐layer (LBL) assembly of functionalized nanoparticles (FNPs) within a polyelectrolyte network is described (see image). The LBL‐NP‐assembly‐based modification can be used to engineer surfaces with multiple functions such as controlled (multiple‐) drug release with distinct release kinetics and enhanced contrast in clinical imaging modalities. This novel surface modification strategy is expected to accelerate the development of bioresponsive coatings for implantable biomedical devices.