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Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery
Author(s) -
Park JiHo,
von Maltzahn Geoffrey,
Ong Luvena L.,
Centrone Andrea,
Hatton T. Alan,
Ruoslahti Erkki,
Bhatia Sangeeta N.,
Sailor Michael J.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200902895
Subject(s) - materials science , drug delivery , payload (computing) , nanotechnology , nanoparticle , nanomaterials , in vivo , nanorod , liposome , biomedical engineering , computer science , biology , medicine , network packet , computer network , microbiology and biotechnology
A cooperative nanosystem consisting of two distinct nanomaterials works in vivo to detect tumor tissues and deliver drugs to the site. Gold nanorods (GNRs) localize to the tumor region, where they report their location and convert near‐infrared radiation to thermal energy. Circulating thermally labile therapeutic liposomes respond to the thermal signal, releasing their drug payload selectively in the GNR‐populated tumor.