Premium
Collagen Biomineralization In Vivo by Sustained Release of Inorganic Phosphate Ions
Author(s) -
Habibovic Pamela,
Bassett David C.,
Doillon Charles J.,
Gerard Catherine,
McKee Marc D.,
Barralet Jake E.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200902778
Subject(s) - biomineralization , mineralization (soil science) , in vivo , apatite , materials science , phosphate , inorganic phosphate , nanocrystal , mineralized tissues , ion , nanotechnology , electron microscope , biophysics , biomedical engineering , mineralogy , chemical engineering , biochemistry , chemistry , biology , composite material , microbiology and biotechnology , medicine , organic chemistry , optics , physics , nitrogen , engineering , dentin
A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter‐fibrillar microcrystals and nanocrystals associated with collagen.