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Elastic Fully Three‐dimensional Microstructure Scaffolds for Cell Force Measurements
Author(s) -
Klein Franziska,
Striebel Thomas,
Fischer Joachim,
Jiang Zhongxiang,
Franz Clemens M.,
von Freymann Georg,
Wegener Martin,
Bastmeyer Martin
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200902515
Subject(s) - microstructure , photoresist , materials science , biocompatible material , calibration , atomic force microscopy , nanotechnology , microscopy , composite material , computer science , biomedical engineering , optics , physics , quantum mechanics , medicine , layer (electronics)
Elastic 3D scaffolds (see figure) are fabricated into a biocompatible photoresist using direct laser writing. These scaffolds can be rhythmically deformed by single beating cardiomyocytes and calibration with atomic force microscopy indicates that cellular forces down to 10–20 nN are detectable with the setup.