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Dynamic Hydrogels: Switching of 3D Microenvironments Using Two‐Component Naturally Derived Extracellular Matrices
Author(s) -
Gillette Brian M.,
Jensen Jacob A.,
Wang Meixin,
Tchao Jason,
Sia Samuel K.
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200902265
Subject(s) - extracellular matrix , component (thermodynamics) , self healing hydrogels , materials science , extracellular , biophysics , matrix (chemical analysis) , calcium alginate , nanotechnology , calcium , composite material , chemistry , polymer chemistry , biochemistry , biology , physics , thermodynamics , metallurgy
This article describes fabrication of a two‐component extracellular matrix (ECM) in which one component acts as a stable structural element and another component gels or dissolves reversibly (a modulatory component). Using a composite collagen‐alginate ECM, reversible crosslinking of the alginate (the modulatory component) via application of calcium or citrate modulates cell mobility in a 3D collagen matrix (the structural component).