Dynamic Hydrogels: Switching of 3D Microenvironments Using Two‐Component Naturally Derived Extracellular Matrices | Zendy

Gillette Brian M. | Zendy; Jensen Jacob A. | Zendy; Wang Meixin | Zendy; Tchao Jason | Zendy; Sia Samuel K. | Zendy

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Dynamic Hydrogels: Switching of 3D Microenvironments Using Two‐Component Naturally Derived Extracellular Matrices

Author(s) -

Gillette Brian M.,

Jensen Jacob A.,

Wang Meixin,

Tchao Jason,

Sia Samuel K.

Publication year - 2010

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200902265

Subject(s) - extracellular matrix , component (thermodynamics) , self healing hydrogels , materials science , extracellular , biophysics , matrix (chemical analysis) , calcium alginate , nanotechnology , calcium , composite material , chemistry , polymer chemistry , biochemistry , biology , physics , thermodynamics , metallurgy

This article describes fabrication of a two‐component extracellular matrix (ECM) in which one component acts as a stable structural element and another component gels or dissolves reversibly (a modulatory component). Using a composite collagen‐alginate ECM, reversible crosslinking of the alginate (the modulatory component) via application of calcium or citrate modulates cell mobility in a 3D collagen matrix (the structural component).

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