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Enzymatic Manipulation of DNA‐Modified Gold Nanoparticles for Screening G‐Quadruplex Ligands and Evaluating Selectivities
Author(s) -
Chen Cuie,
Zhao Chuanqi,
Yang Xinjian,
Ren Jinsong,
Qu Xiaogang
Publication year - 2010
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200901924
Subject(s) - nanotechnology , nanoparticle , combinatorial chemistry , colloidal gold , dna , g quadruplex , materials science , duplex (building) , selectivity , computational biology , chemistry , biochemistry , biology , catalysis
Enzymatic manipulation of DNA on well‐dispersed gold nanoparticles (AuNPs) offers an ideal system for high‐throughput screening of G‐quadruplex ligands and evaluation of their selectivity with respect to duplex and quadruplex DNA (see figure). This work has implications for the future use of nanoparticle‐based technologies in the discovery of potential cancer therapeutic agents.