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Dynamic, 3D‐Pattern Formation Within Enzyme‐Responsive Hydrogels
Author(s) -
Straley Karin S.,
Heilshorn Sarah C.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200901865
Subject(s) - self healing hydrogels , payload (computing) , materials science , nanotechnology , void (composites) , enzyme , composite number , sequence (biology) , computer science , biophysics , computational biology , biochemistry , biology , polymer chemistry , composite material , computer network , network packet
Dynamic, 3D hydrogel patterns emerge over time in response to cell‐secreted enzymes (see image). Composite hydrogels fabricated from engineered proteins exhibit customized half‐lives ranging across two orders of magnitude due to slight changes in the primary amino acid sequence. The evolution of internal 3D void structures within these polymeric materials is used to release multiple payload molecules with distinct spatial and temporal delivery profiles.