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A Versatile Synthetic Extracellular Matrix Mimic via Thiol‐Norbornene Photopolymerization
Author(s) -
Fairbanks Benjamin D.,
Schwartz Michael P.,
Halevi Alexandra E.,
Nuttelman Charles R.,
Bowman Christopher N.,
Anseth Kristi S.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200901808
Subject(s) - photopolymer , norbornene , ethylene glycol , self healing hydrogels , materials science , nanotechnology , thiol , polymer science , polymer , polymer chemistry , organic chemistry , chemistry , polymerization , composite material
Step‐growth, radically mediated thiol‐norbornene photopolymerization is used to create versatile, stimuli‐responsive poly(ethylene glycol)‐co‐peptide hydrogels (see image) The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three‐dimensional biochemical photopatterning.