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Surface‐Treatment‐Induced Three‐Dimensional Capillary Morphogenesis in a Microfluidic Platform
Author(s) -
Chung Seok,
Sudo Ryo,
Zervantonakis Ioannis K.,
Rimchala Tharathorn,
Kamm Roger D.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200901727
Subject(s) - capillary action , materials science , microfluidics , surface (topology) , matrix (chemical analysis) , nanotechnology , angiogenesis , morphogenesis , content (measure theory) , computer science , biomedical engineering , biology , biochemistry , composite material , medicine , gene , cancer research , geometry , mathematics , mathematical analysis
Robust induction of realistic angiogenesis into a 3D matrix material under simultaneous imaging and a stably controlled concentration gradient of chemoattractants is presented. The formation of a 3D vascular network is demonstrated to be a direct consequence of surface treatment of the region of the device‐containing matrix material.