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Nonblinking and Nonbleaching Upconverting Nanoparticles as an Optical Imaging Nanoprobe and T1 Magnetic Resonance Imaging Contrast Agent
Author(s) -
Park Yong Il,
Kim Jeong Hyun,
Lee Kang Taek,
Jeon KiSeok,
Na Hyon Bin,
Yu Jung Ho,
Kim Hyung Min,
Lee Nohyun,
Choi Seung Hong,
Baik SungIl,
Kim Hyoungsu,
Park Seung Pyo,
Park BeomJin,
Kim Young Woon,
Lee Sung Ho,
Yoon SooYoung,
Song In Chan,
Moon Woo Kyung,
Suh Yung Doug,
Hyeon Taeghwan
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200901356
Subject(s) - nanoprobe , materials science , magnetic resonance imaging , nanoparticle , contrast (vision) , optical imaging , nuclear magnetic resonance , nanotechnology , optics , medicine , radiology , physics
Core/shell upconverting nanoparticles (UCNPs) of NaGdF 4 :Er 3+ ,Yb 3+ /NaGdF 4 (see figure) are shown to serve as a multimodal imaging probe that works for both background‐free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long‐term imaging experiments. Owing to Gd 3+ ions in the host matrix, contrast is enhanced in T 1 ‐weighted MRI.