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Ultrabubble: A Laminated Ultrasound Contrast Agent with Narrow Size Range
Author(s) -
Lin PeiLun,
Eckersley Robert J.,
Hall Elizabeth A. H.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200901096
Subject(s) - materials science , dispersity , ultrasound , contrast (vision) , nanoparticle , shell (structure) , nanotechnology , pressure sensitive , biomedical engineering , composite material , acoustics , optics , polymer chemistry , medicine , physics , adhesive , layer (electronics)
A laminated shell microcapsule is described resisting aggregation and withstanding ultrasound destruction, showing a good backscatter signal, as shown in the figure. Templated synthesis produces versatile monodisperse capsules <3 µm, with ultrasound‐pressure dependency allowing rupture above MI ∼ 1.5 (at 2 MHz), suitable for future development as both controlled‐delivery agent and contrast agent.