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Microstructured Surfaces Cause Severe but Non‐Detrimental Deformation of the Cell Nucleus
Author(s) -
Davidson Patricia M.,
Özçelik Hayriye,
Hasirci Vasif,
Reiter Günter,
Anselme Karine
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200900582
Subject(s) - deformation (meteorology) , materials science , nucleus , nanotechnology , organelle , surface (topology) , micrometer , biophysics , biology , microbiology and biotechnology , composite material , physics , optics , geometry , mathematics
Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer‐sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.