Aldehyde‐Amine Chemistry Enables Modulated Biosealants with Tissue‐Specific Adhesion | Zendy

Artzi Natalie | Zendy; Shazly Tarek | Zendy; Baker Aaron B. | Zendy; Bon Adriana | Zendy; Edelman Elazer R. | Zendy

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Aldehyde‐Amine Chemistry Enables Modulated Biosealants with Tissue‐Specific Adhesion

Author(s) -

Artzi Natalie,

Shazly Tarek,

Baker Aaron B.,

Bon Adriana,

Edelman Elazer R.

Publication year - 2009

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200900340

Subject(s) - adhesive , adhesion , materials science , sealant , amine gas treating , dextran , tissue adhesion , peg ratio , biomedical engineering , chemical engineering , biophysics , nanotechnology , composite material , chemistry , organic chemistry , biology , medicine , layer (electronics) , engineering , finance , economics

The interfacial regions between PEG: dextran‐based adhesive sealant and excised rat heart, lung, liver, and duodenum tissues exhibit three distinct domains; target tissue (red and blue), bulk material (green), and an adhesive regime interposed between the two. The variation in adhesive regime morphology when applied to different tissues provides a rational approach for the engineering of application‐specific surgical sealants.

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