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Aldehyde‐Amine Chemistry Enables Modulated Biosealants with Tissue‐Specific Adhesion
Author(s) -
Artzi Natalie,
Shazly Tarek,
Baker Aaron B.,
Bon Adriana,
Edelman Elazer R.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200900340
Subject(s) - adhesive , adhesion , materials science , sealant , amine gas treating , dextran , tissue adhesion , peg ratio , biomedical engineering , chemical engineering , biophysics , nanotechnology , composite material , chemistry , organic chemistry , biology , medicine , layer (electronics) , engineering , finance , economics
The interfacial regions between PEG: dextran‐based adhesive sealant and excised rat heart, lung, liver, and duodenum tissues exhibit three distinct domains; target tissue (red and blue), bulk material (green), and an adhesive regime interposed between the two. The variation in adhesive regime morphology when applied to different tissues provides a rational approach for the engineering of application‐specific surgical sealants.