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Translating Electronic Currents to Precise Acetylcholine–Induced Neuronal Signaling Using an Organic Electrophoretic Delivery Device
Author(s) -
Tybrandt Klas,
Larsson Karin C.,
Kurup Sindhulakshmi,
Simon Daniel T.,
Kjäll Peter,
Isaksson Joakim,
Sandberg Mats,
Jager Edwin W. H.,
RichterDahlfors Agneta,
Berggren Magnus
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200900187
Subject(s) - acetylcholine , materials science , biomolecule , nanotechnology , polymer , biophysics , biology , endocrinology , composite material
A miniaturized organic electronic ion pump (OEIP) based on conjugated polymers is developed for delivery of positively charged biomolecules. Characterization shows that applied voltage can precisely modulate the delivery rate of the neurotransmitter acetylcholine. The capability of the device is demonstrated by convection‐free, spatiotemporally resolved delivery of acetylcholine via a 10 µm channel for dynamic stimulation of single neuronal cells.