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Inside Front Cover: Enzyme‐Based Multi‐Component Optical Nanoprobes for Sequence‐Specific Detection of DNA Hybridization (Adv. Mater. 3/2008)
Author(s) -
Li J.,
Song S.,
Liu X.,
Wang L.,
Pan D.,
Huang Q.,
Zhao Y.,
Fan C.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200890008
Subject(s) - nanoprobe , horseradish peroxidase , materials science , bovine serum albumin , dna , biosensor , colloidal gold , nanoparticle , nanotechnology , combinatorial chemistry , hybridization probe , microbiology and biotechnology , enzyme , biochemistry , chemistry , biology
Abstract A novel multicomponent gold nanoparticle (AuNP)‐based nanoprobe can be assembled from a thiolated DNA detection probe, horseradish peroxidase (HRP), and bovine serum albumin (BSA), report Shiping Song, Yun Zhao, Chunhui Fan, and co‐workers on p. 497. The DNA detection probe is employed to construct a complex for “sandwich”‐based DNA detection, the HRP translates the hybridization event into an enzymatic catalysis‐based optical signal, and BSA serves as a non‐specific blocker.