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Entering and Lighting Up Nuclei Using Hollow Chitosan–Gold Hybrid Nanospheres
Author(s) -
Hu Yong,
Chen Qi,
Ding Yin,
Li Rutian,
Jiang Xiqun,
Liu Baorui
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200803682
Subject(s) - materials science , drug delivery , nanotechnology , chitosan , aqueous solution , anticancer drug , drug , chemical engineering , chemistry , organic chemistry , medicine , engineering , psychiatry
Functional hollow CS–PAA–Au‐hybrid nanospheres are prepared in aqueous solution via a one‐pot route. These hollow hybrid nanospheres can not only act as drug carriers for intracellular and intranuclear drug delivery, but also act as a contrast agent in cancer‐cell imaging, and light up the nucleus. This results in a nanosphere that can execute tumor‐cell imaging and anticancer drug delivery at the same time.