Simple Fabrication of Antibody Microarrays on Nonfouling Polymer Brushes with Femtomolar Sensitivity for Protein Analytes in Serum and Blood | Zendy

Hucknall Angus | Zendy; Kim DongHwan | Zendy; Rangarajan Srinath | Zendy; Hill Ryan T. | Zendy; Reichert William M. | Zendy; Chilkoti Ashutosh | Zendy

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Simple Fabrication of Antibody Microarrays on Nonfouling Polymer Brushes with Femtomolar Sensitivity for Protein Analytes in Serum and Blood

Author(s) -

Hucknall Angus,

Kim DongHwan,

Rangarajan Srinath,

Hill Ryan T.,

Reichert William M.,

Chilkoti Ashutosh

Publication year - 2009

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200803125

Subject(s) - atom transfer radical polymerization , analyte , ethylene glycol , methacrylate , polymer , polymer brush , materials science , peg ratio , combinatorial chemistry , polymerization , polymer chemistry , nanotechnology , chemistry , chromatography , organic chemistry , finance , economics , composite material

A multianalyte antibody array that is spotted on a poly(oligo(ethylene glycol) methacrylate) brush 100 nm thick, grown on glass via surface‐initiated atom transfer radical polymerization, has femtomolar limit‐of‐detection (LOD) of cytokines in serum and whole blood, and a dynamic range of six orders of magnitude for a range of protein analytes.

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