Premium
Photonic Shell‐Crosslinked Nanoparticle Probes for Optical Imaging and Monitoring
Author(s) -
Lee Nam S.,
Sun Guorong,
Neumann William L.,
Freskos John N.,
Shieh Jeng J.,
Dorshow Richard B.,
Wooley Karen L.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200803053
Subject(s) - fluorophore , materials science , fluorescence , nanoparticle , covalent bond , nanostructure , nanotechnology , polymer , photonics , chemical engineering , photochemistry , optoelectronics , optics , chemistry , composite material , organic chemistry , physics , engineering
A pH‐insensitive fluorophore is fabricated to give pH‐driven responses through its covalent incorporation within a nanostructure derived from pH‐responsive polymers. Fluorophore shell‐crosslinked nanoparticles (SCKs) demonstrate notable enhancement of photophysical properties in the physiological pH region. Fluorophore SCKs are designed to swell at higher pH values and shrink as the pH is lowered, producing high fluorescence versus low fluorescence outputs, respectively.