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Rapid Microfluidic Generation of Patterned Aldehydes from Hydroxy‐Terminated Self‐Assembled Monolayers for Ligand and Cell Immobilization on Optically Transparent Indium Tin Oxide Surfaces
Author(s) -
Pulsipher Abigail,
Westcott Nathan P.,
Luo Wei,
Yousaf Muhammad N.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200802503
Subject(s) - self assembled monolayer , materials science , indium tin oxide , monolayer , aldehyde , oxidizing agent , microfluidics , ligand (biochemistry) , tin , indium , nanotechnology , oxide , chemical engineering , combinatorial chemistry , organic chemistry , catalysis , chemistry , optoelectronics , layer (electronics) , metallurgy , biochemistry , receptor , engineering
Selective immobilization of a wide range of ligands on an indium tin oxide (ITO) surface is demonstrated. A chemoselective immobilization strategy to tailor ITO surfaces is developed by selectively oxidizing hydroxyl‐terminated phosphonate self‐assembled monolayers (SAMs) to aldehyde‐presenting SAMs using microfluidic channels and then reacting with oxyamine‐containing ligands — all on a chip.