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Bone‐like Resorbable Silk‐based Scaffolds for Load‐bearing Osteoregenerative Applications
Author(s) -
Collins Andrew M.,
Skaer Nick J. V.,
Gheysens Tom,
Knight David,
Bertram Caroline,
Roach Helmtrud I.,
Oreffo Richard O. C.,
VonAulock Sonja,
Baris Teodora,
Skinner John,
Mann Stephen
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200802239
Subject(s) - fibroin , materials science , load bearing , composite material , silk , toughness , cancellous bone , compressive strength , biocompatible material , biocompatibility , mechanical strength , flexural strength , biomedical engineering , medicine , pathology , metallurgy
Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone‐like composites areabsorbable and load‐bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.