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Binding, Internalization, and Antigen Presentation of Vaccine‐Loaded Nanoengineered Capsules in Blood
Author(s) -
De Rose Robert,
Zelikin Alexander N.,
Johnston Angus P. R.,
Sexton Amy,
Chong SiowFeng,
Cortez Christina,
Mulholland William,
Caruso Frank,
Kent Stephen J.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200801826
Subject(s) - internalization , antigen , antigen presentation , materials science , dendritic cell , in vivo , antigen presenting cell , microbiology and biotechnology , nanotechnology , immunology , biophysics , cell , biology , immune system , t cell , biochemistry
Nanoengineered microcapsules (shown in green) can be used to encapsulate vaccine antigens conferring protection of the cargo until the capsules are taken up by specialized antigen presenting cells in human blood such as dendritic cells (cell membrane in red, nucleus in blue). This technique offers potential applications for in vivo vaccine delivery.