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Exploring Optical Properties of Liquid Crystals for Developing Label‐Free and High‐Throughput Microfluidic Immunoassays
Author(s) -
Xue ChangYing,
Khan Saif A.,
Yang KunLin
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200801803
Subject(s) - microfluidics , materials science , naked eye , nanotechnology , molecular binding , multiplexing , throughput , liquid crystal , optoelectronics , detection limit , chromatography , molecule , chemistry , computer science , telecommunications , organic chemistry , wireless
The orientational transition of liquid crystals (LCs) is used as a label‐free detection mechanism for immunoassays developed in microfluidic systems. LCs only show bright optical textures (visible to the naked eye) in the line‐line intersections in which label‐free antibodies bind to their surface‐immobilized antigens, suggesting the feasibility of using LCs to detect specific antigen‐antibody binding events in a high‐throughput and multiplexed manner.