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Step‐by‐Step Build‐Up of Biologically Active Cell‐Containing Stratified Films Aimed at Tissue Engineering
Author(s) -
Grossin Laurent,
Cortial Delphine,
Saulnier Benjamin,
Félix Olivier,
Chassepot Armelle,
Decher Gero,
Netter Patrick,
Schaaf Pierre,
Gillet Pierre,
Mainard Didier,
Voegel JeanClaude,
BenkiraneJessel Nadia
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200801541
Subject(s) - tissue engineering , biological tissue , materials science , engineering , biomedical engineering
Alginate gel layers containing viable cells with adjacent bioactive polyelectrolyte multilayers are fabricated, and their bioactivity is shown to originate mainly from the degradation of the cells. Alternate biofunctionalized multilayers and cell‐containing layers are shown to be an essential step toward fabrication of stratified architectures, and tuning the cellular activity is possible by controlling the position of active molecules.