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Size‐Dependent Endocytosis of Nanoparticles
Author(s) -
Zhang Sulin,
Li Ju,
Lykotrafitis George,
Bao Gang,
Suresh Subra
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200801393
Subject(s) - endocytosis , nanoparticle , materials science , drug delivery , radius , nanotechnology , rational design , particle size , particle (ecology) , nanomedicine , biophysics , chemical engineering , chemistry , computer science , biology , biochemistry , cell , ecology , computer security , engineering
The cellular uptake of nanoparticles by living cells is predicted to be strongly size‐dependent, according the thermodynamic analysis, and an optimal particle radius of ∼ 25–30 nm at which the cellular uptake reaches a maximum of several thousand is shown to exist. The theoretical prediction provides valuable guidance for the rational design of nanoparticle‐based drug‐delivery systems.