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Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings
Author(s) -
Lee Haeshin,
Rho Junsung,
Messersmith Phillip B.
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200801222
Subject(s) - biomolecule , bioconjugation , nanotechnology , materials science , coating , surface modification , adhesive , combinatorial chemistry , chemistry , layer (electronics)
A new surface bioconjugation strategy is presented. A polydopamine surface coating provides chemical activation on material surfaces, is resistant to hydrolysis, and offers selectivity in coupling of biomolecules via nucleophilic groups through simple pH control. Control of orientation of immobilized biomolecules may be possible using terminally modified DNA or His‐containing proteins.